The chemicals Yel002 and CJ010 were isolated from 16,000 chemicals from a chemical library as treatments against radiation induced genotoxicity and genetic instability. After radiation with a lethal dose that killed 100% of the mice and the first injection of Yel002 24 hours after radiation we could rescue 100%. Yel002 is also active against UV, and toxic chemicals and carcinogens EMS, MMS, nitrogen mustard, radioactive iodine and cigarette smoke extract induced DNA damage. Yel002 and CJ010 reduced radiation induced leukemia from 90% to 40% and the spontaneous frequency from 10% to 0%. Weekly subcutaneous injections of Yel002 also extended the life expectancy of cancer prone Atm deficient mice of which usually 90% die from lymphoma for 16 weeks which is about 12 years of human life expectancy. Yel002 also extended the life span in a senescence assay after radiation 2 fold and spontaneous senescence 15%. The mechanism of action seems to be induction of DNA repair, namely ATM signalling, homologous recombination, and end joining, base excision repair and chromosome segregation functions.